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Cymbalta Alternate options to Contemplate — Talkspace

Revealed on: 30 Nov 2023

Alternatives to Cymbalta

Cymbalta (duloxetine) is a standard antidepressant for treating despair and anxiousness. It’s additionally generally prescribed for diabetic peripheral neuropathy and different medical situations that trigger ache, like arthritis, fibromyalgia, and persistent again ache. Cymbalta is in a category of medicine referred to as serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs steadiness norepinephrine and serotonin ranges — neurotransmitters related to temper regulation and application — within the mind.

Whereas Cymbalta might be very efficient for some folks, it’s not all the time the precise treatment for everybody. It would trigger undesirable Cymbalta unwanted side effects, antagonistic drug interactions, not be efficient in relieving signs, otherwise you would possibly simply be searching for pure alternate options to Cymbalta use. Holistic therapy choices have gotten extra interesting and acquainted, whether or not mixed with treatment or remedy or when used independently. 

No matter your motive is for trying into Cymbalta alternate options, we’re diving into all the pieces it’s essential to learn about pure treatments and different medicine just like Cymbalta. 

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Different Drugs to Cymbalta

There are a number of medicines which may be viable alternate options to Cymbalta for despair or different situations. Since each drug has distinctive traits, advantages, dangers, and unwanted side effects, exploring every choice and checking with a healthcare supplier is important earlier than switching from Cymbalta.

1. Lexapro 

Lexapro (escitalopram) is an alternative choice to Cymbalta that is perhaps good for people who find themselves involved about Cymbalta’s results when used long-term. Lexapro is within the class of medicine referred to as selective serotonin reuptake inhibitors (SSRIs), which work by rising serotonin ranges within the mind to boost temper. There are a lot of features to contemplate when taking a look at Cymbalta vs Lexapro.

Variations between Cymbalta and Lexapro: 

  • Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) whereas Lexapro is a selective serotonin reuptake inhibitor (SSRI).
  • Cymbalta is FDA-approved to deal with extra situations than Lexapro.
  • There is perhaps fewer antagonistic unwanted side effects of Lexapro than Cymbalta.
  • In some research, Lexapro was more practical in treating main depressive dysfunction (MDD).

Similarities between Cymbalta and Lexapro: 

  • Each can deal with main depressive dysfunction (MDD) and anxiousness
  • Each medicine shouldn’t be used with the rest that will increase serotonin ranges.
  • Cymbalta and Lexapro shouldn’t be used with NSAIDs or different medicine that may trigger bleeding.

2.Effexor (venlafaxine)

Effexor is perhaps a great choice to discover because it’s one of many medicine just like Cymbalta. As a result of they’re in the identical class of antidepressants — SNRIs — they work equally.

Nonetheless, it’s essential to notice that Effexor might trigger vital blood stress adjustments in comparison with different antidepressants. So, monitoring your BP usually and consulting a medical skilled when taking this drug is vital. 

Variations between Cymbalta and Effexor: 

  • Cymbalta is used to deal with extra medical situations.
  • Effexor might be an choice to deal with panic dysfunction and social anxiousness dysfunction.
  • Effexor is extra prone to lower intercourse drive as a aspect impact.
  • Cymbalta is stronger and can be utilized in decrease doses.

Similarities between Cymbalta and Effexor: 

  • Cymbalta and Effexor are each SNRIs.
  • Each medicine can deal with MDD and generalized anxiousness dysfunction (GAD).
  • Shared unwanted side effects embrace dry mouth, drowsiness, lack of urge for food, and nausea.
  • Neither drug must be used along with monoamine oxidase inhibitors (MAOIs).

3. Prozac (fluoxetine)

Prozac is a standard and standard antidepressant treatment within the SSRI class of medicine. It’s prescribed to deal with main depressive dysfunction and obsessive-compulsive dysfunction. It’s additionally authorised to deal with the consuming dysfunction bulimia and panic dysfunction in adults.

Variations between Cymbalta and Prozac:

  • They’re in numerous courses of medicine — Cymbalta is an SNRI and Prozac is an SSRI.
  • Prozac is authorised to deal with extra psychological well being situations.
  • Prozac can be utilized to deal with some disordered consuming situations.
  • Cymbalta is authorised to deal with ache associated to some medical situations, whereas Prozac shouldn’t be.

Similarities between Cymbalta and Prozac:

  • Cymbalta and Prozac can be utilized to deal with main depressive dysfunction.
  • Research recommend that each medicine have comparable efficacy and security outcomes.

4. Wellbutrin (bupropion)

Wellbutrin is an antidepressant authorised to deal with main depressive dysfunction (MDD) and seasonal affective dysfunction (SAD). It’s additionally prescribed for smoking cessation. Within the norepinephrine and dopamine reuptake inhibitors (NDRIs) class of medicine, Wellbutrin has a number of the identical antagonistic results as Cymbalta, together with the potential to trigger dry mouth, dizziness, problem sleeping or insomnia, and nausea. 

Variations between Cymbalta and Wellbutrin:

  • Cymbalta and Wellbutrin belong to completely different courses of medicine.
  • Cymbalta could cause diarrhea and fatigue; Wellbutrin usually doesn’t.
  • Wellbutrin is perhaps a greater choice for individuals who expertise weight acquire on Cymbalta.

Similarities between Cymbalta and Wellbutrin:

  • Each medicine are used to deal with sure varieties of ache.
  • Each Cymbalta and Wellbutrin might be efficient in treating despair.
Drug Class of Medicine Treatable Circumstances Frequent Aspect Results
Cymbalta (duloxetine) SNRI Main depressive dysfunction
Common anxiousness dysfunction
Nerve ache attributable to diabetes
Power muscle and joint ache
Dry mouth
Lack of urge for food
Elevated sweating
Lexapro (escitalopram) SSRI Main depressive dysfunction
Generalized anxiousness dysfunction
Dry mouth
Problem sleeping
Diarrhea or constipation
Sexual dysfunction
Dizziness or drowsiness
Effexor (venlafaxine) SNRI Despair
Generalized anxiousness dysfunction
Panic dysfunction
Social anxiousness dysfunction
Dry mouth 
Lack of urge for food
Blurred imaginative and prescient
Prozac (fluoxetine) SSRI Main depressive dysfunction
compulsive dysfunction
Panic dysfunction
Bipolar despair
Lack of urge for food
Problem sleeping
Wellbutrin (bupropion) NDRIs Despair
Seasonal have an effect on dysfunction
Smoking cessation
Sleep points
Dry mouth

Pure Alternate options to Cymbalta

Drugs like Cymbalta can work effectively for some folks, however others would possibly desire a pure various. Whether or not it’s to keep away from unwanted side effects or since you want a holistic strategy, there are a number of non-pharmaceutical Cymbalta alternate options obtainable.

6. Omega-3 fatty acids

Omega-3 fatty acids are identified for coronary heart well being advantages and the power to help psychological well being. Omega-3s are vital to mind perform and efficiency, and a few analysis has proven they’ll cut back signs of despair. Omega-3s are discovered naturally in meals sources like salmon or they’re obtainable as dietary supplements.

7. Vitamin D

Generally known as the sunshine vitamin, Vitamin D can increase temper, which could make it a possible various to Cymbalta for despair. Research have discovered that folks with despair usually have low vitamin D ranges, so supplementing would possibly assist.

8. L-theanine

L-theanine is a novel amino acid present in inexperienced tea leaves. It’s gained reputation lately because of the calming impact it could have on the physique and thoughts. In analysis, l-theanine has been proven to be efficient in stress aid, temper enhancement, and improved sleep high quality.

9. Life-style adjustments 

Adjusting your way of life by specializing in wholesome habits could be a shocking various to Cymbalta that many individuals may not take into account. Implement the next into your days to see for those who discover a discount in depressive signs and anxiousness.

  • Work out usually: Analysis exhibits that getting the center charge up releases endorphins, referred to as the feel-good hormones. Even one thing so simple as strolling briskly day by day can enhance your temper.
  • Eat wholesome: Attempt to eat a balanced weight loss program filled with nutrient-rich meals. It might not treatment your despair, however it could assist naturally raise your temper.
  • Follow mindfulness: Conscious actions like meditation and journaling can change your mindset and enhance your temper.
  • Search remedy: Numerous research have confirmed the improved efficacy of mixing remedy and medicine vs. utilizing one or the opposite alone.

“Remedy is an effective way to develop perception into signs and analysis. It helps to facilitate consciousness and understanding of the problems that the individual is dealing with. You can too be taught well being coping methods to assist handle signs. Typically treatment and remedy are mixed to deal with the individual and have a constructive consequence.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Concerns for Switching to a Cymbalta Different

When you’re contemplating switching from a medicine like Cymbalta to a special drug or a holistic therapy plan, there are a number of essential components to recollect. Discovering an acceptable various is just potential if it suits your distinctive wants and targets for enchancment.

Contemplate the next:

  • Why do you need to transition from Cymbalta?
  • Do the unwanted side effects of the drug outweigh any constructive outcomes?
  • Have you ever talked to your physician about different drugs you’re at present taking?

“You will need to work carefully together with your psychiatrist when switching drugs to keep away from Cymbalta withdrawal. Focus on and be open about your signs and issues together with your suppliers so they’re conscious of how you might be doing.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Discover the Proper Different with Talkspace 

When you’re making an attempt to resolve whether or not to vary drugs or take a holistic strategy to your therapy plan — or for those who’re interested by combining medication with remedy or non-pharmaceutical therapy choices — Talkspace is right here. 

Talkspace is a web-based platform with a crew of psychological well being professionals who can present remedy, prescriptions, and medicine administration.

We provide telehealth from the consolation of your own home as you make vital selections about your treatment and therapy plan. Our crew is right here that will help you navigate the complexities of treatment adjustments.


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Talkspace articles are written by skilled psychological health-wellness contributors; they’re grounded in scientific analysis and evidence-based practices. Articles are extensively reviewed by our crew of scientific specialists (therapists and psychiatrists of assorted specialties) to make sure content material is correct and on par with present trade requirements.

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